Registration Dossier
Registration Dossier
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EC number: 201-744-0 | CAS number: 87-41-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Pulmonary toxicity of 2-isopropylnaphthalene and its photoproducts
- Author:
- Honda, T. et al.
- Year:
- 1 991
- Bibliographic source:
- Eisei Kagaku 37 (4), 300-306 (1991). DIMDI-Toxall, ND: BI9200787
- Reference Type:
- secondary source
- Title:
- ECB-IUCLID Dataset Phthalide, CAS No. 87-41-2
- Author:
- ECB
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
- Type of study / information:
- pulmonary toxicity
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Phthalide
- EC Number:
- 201-744-0
- EC Name:
- Phthalide
- Cas Number:
- 87-41-2
- Molecular formula:
- C8H6O2
- IUPAC Name:
- 1(3H)-Isobenzofuranone
- Details on test material:
- - Name of test material (as cited in study report): Phthalide
Constituent 1
Results and discussion
Any other information on results incl. tables
24 h after administration damages of the lung were observed (no further comments). The maximal tissue concentration of the substance was reached 1 - 2 h after application and decreased rapidly. The injections phthalide caused considerable depletion of pulmonary GSH (reduced glutathione) at 12 h after the administration of the compound. These results suggested that reactive metabolites such as epoxides were produced and interacted with GSH.
Applicant's summary and conclusion
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