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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA.
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Prediction done using ECOSAR v.1.11 model
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material: 4-chloro-1-methylpiperidinium chloride
- IUPAC name: 4-chloro-1-methylpiperidin-1-ium chloride
- Molecular formula: C6H13Cl2N
- Molecular weight: 170.0817 g/mole
- Smiles : CN1CCC(CC1)Cl.Cl
- Inchl: 1S/C6H12ClN.ClH/c1-8-4-2-6(7)3-5-8;/h6H,2-5H2,1H3;1H
- Substance type: Organic
- Physical state: Solid crystal powder (White - Slightly pale yellow)
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
static
Water media type:
not specified
Limit test:
no
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
261.62 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: not toxic
Conclusions:
On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 261.626 mg/l for 4-chloro-1-methylpiperidinium chloride in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-chloro-1-methylpiperidinium chloride as not toxic to aquatic environment.
Executive summary:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 261.626 mg/l for 4-chloro-1-methylpiperidinium chloride in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-chloro-1-methylpiperidinium chloride as not toxic to aquatic environment.and thus can be considered “not classified” per the CLP criteria.

Description of key information

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 261.626 mg/l for 4-chloro-1-methylpiperidinium chloride in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-chloro-1-methylpiperidinium chloride as not toxic to aquatic environment.and thus can be considered “not classified” per the CLP criteria.

Key value for chemical safety assessment

LC50 for freshwater fish:
261.62 mg/L

Additional information

Following studies of target chemical includes data from prediction model and Authoritative database to conclude the toxicity extent of 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) is summarized as follows:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 261.626 mg/l for 4-chloro-1-methylpiperidinium chloride in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-chloro-1-methylpiperidinium chloride as not toxic to aquatic environment and thus can be considerednot classifiedper the CLP criteria.

Similar predicted data from Danish QSAR database indicates that the estimated 96 hrs LC50 value of 4-Chloro-1-methylpiperidinium chloride(CAS: 5382-23-0) on Fathead minnow by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database is 133.89 mg/L. It can be concluded from the estimated value that the 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) is not toxic to aquatic environment and can be considered as "not classified" as per CLP regulation.

Thus based on the effect concentrations which is in the range 133.89 mg/L mg/l to 261.626 give the conclusion that test substance 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) was likely to be not toxic to fish at environmentally relevant concentrations and can be considered to benot classifiedas per the CLP classification criteria.