4-chloro-1-methylpiperidinium chloride

Endpoint summary

Description of key information

Short-term toxicity to fish

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 261.626 mg/l for 4-chloro-1-methylpiperidinium chloride in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-chloro-1-methylpiperidinium chloride as not toxic to aquatic environment.and thus can be considered “not classified” per the CLP criteria.

Short-term toxicity to aquatic invertebrates

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic invertebrate predicted for 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0). Effect concentration i.e EC50 value estimated to be 191.27 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0) likely to be not toxic to aquatic invertebrates, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

Toxicity to aquatic algae and cyanobacteria

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on algae was predicted 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0). Effect concentration i.e EC50 value was estimated to be 145.22 mg/l for Pseudokirchneriella for 72 hrs duration. It was concluded that the 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0) was likely to be not toxic to aquatic algae, hence it can be considered to be “not Classified” as per the CLP classification criteria for aquatic environment.

Additional information

Short-term toxicity to fish

Following studies of target chemical includes data from prediction model and Authoritative database to conclude the toxicity extent of 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) is summarized as follows:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 261.626 mg/l for 4-chloro-1-methylpiperidinium chloride in 96 hrs. Based on the LC50 value, it can be concluded that the substance 4-chloro-1-methylpiperidinium chloride as not toxic to aquatic environment and thus can be considered“not classified”per the CLP criteria.

Similar predicted data from Danish QSAR database indicates that the estimated 96 hrs LC50 value of 4-Chloro-1-methylpiperidinium chloride(CAS: 5382-23-0) on Fathead minnow by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database is 133.89 mg/L. It can be concluded from the estimated value that the 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) is not toxic to aquatic environment and can be considered as "not classified" as per CLP regulation.

Thus based on the effect concentrations which is in the range 133.89 mg/L mg/l to 261.626 give the conclusion that test substance 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) was likely to be not toxic to fish at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.

Short-term toxicity to aquatic invertebrates

Following four studies of target chemical and read across includes predicted data and experimental data to conclude the toxicity extent of 4-Chloro-1-methylpiperidinaium chloride (CAS: 5382-23-0) is summarized as follows:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic invertebrate predicted for 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0). Effect concentration i.e EC50 value estimated to be 191.27 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0) likely to be not toxic to aquatic invertebrates, hence it can be considered to be“not classified”as per the CLP classification criteria for aquatic environment.

Similar predicted data is from EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to aquatic invertebrate was predicted to be 142.90 mg/l for 4-chloro-1-methylpiperidinium chloride in 48 hrs. Based on the LC50 value, it can be concluded that the substance 4-chloro-1-methylpiperidinium chloride as not toxic to aquatic environment.

The above predicted studies is supported by the experimental study of read across chemical Morpholine (CAS: 110-91-8) from Chemosphere 1980 suggests that the Inhibition concentration to 50% of Daphnia magna for 24 h is 119 mg/L. At which mobility of 50% of population of daphnia magna was measured as effect. On the basis of the value it can be concluded that the Morpholine is not toxic to the aquatic environment.

 

Another experimental study available for the read across 2,2'-iminodiethanol (CAS: 111-42-2) from Archives of Environmental Contamination and Toxicology 1986, indicates that the Lethal concentration LC50 to 50% of Daphnia magna at 48 h is 109 mg/l. Considering the increasing trend of mortality of Daphnia magna population as effect. It can be concluded that the 2,2'-iminodiethanol is not toxic to the aquatic environment.

 

Thus based on the effect concentrations which is in the range 109 mg/L mg/l to 191.27 mg/l give the conclusion that test substance 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) was likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria

Following three studies of target chemical and read across includes predicted data and experimental data to conclude the toxicity extent of 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) is summarized as follows:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primarydescriptor and considering the closest read across substances, the toxicity on algae was predicted 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0). Effect concentration i.e EC50 value was estimated to be 145.22 mg/l for Pseudokirchneriella for 72 hrs duration. It was concluded that the 4-chloro-1-methylpiperidin-1-ium chloride (CAS: 5382-23-0) was likely to be not toxic to aquatic algae, hence it can be considered to be“not Classified”as per the CLP classification criteria for aquatic environment.

 

The above predicted study is supported by the experimental study of read across chemical Atenolol (CAS: 29122-68-7) from Chemosphere 2005 suggests that the Effective concentration EC50 to 50% of Desmodesmus Subspicatus (Green Algae) at 72 h is 620 mg/L for Atenolol. The Population (chlorophyll) effect were measured as effect. It can be concluded that the Atenolol is not toxic to the aquatic environment.

 

Another experimental study available for the read across 2,2'-iminodiethanol (CAS: 111-42-2) from Environmental Toxicology and Chemistry 1989, indicates that The No observable effect concentration (NOEC) to Skeletonema costatum at 5 days is 216 mg/l. It can be concluded from the effect value that the Atenolol is not toxic to the aquatic environment.

 

Thus based on the effect concentrations which is in the range 145.22 mg/L mg/l to 620 mg/l give the conclusion that test substance 4-Chloro-1-methylpiperidinium chloride (CAS: 5382-23-0) was likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.