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Environmental fate & pathways

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Description of key information

Biodegradation in water:

Biodegrdability of test chemical 4-chloro-1-methylpiperidinium chloride (CAS no. 5382 -23 -0) is predicted using OECD QSAR tool box v.3.3using log Kow as primary descriptor. The test chemical 4-chloro-1-methylpiperidinium chloride showed only 1 % biodegradation by BOD parameter and microorganisms as inoculum in 28 days. Since percentage of biodegradation is very less this chemical is considered as not readily biodeegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-chloro-1-methylpiperidinium chloride(CAS No: 5382 -23 -0) .If released in to the environment, 25.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 4-chloro-1-methylpiperidinium chloride in water is estimated to be 37.5 days (900 hrs). The half-life ( 37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 4-chloro-1-methylpiperidinium chloride in sediment is estimated to be 337.5 days (8100 hrs).  However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.154 %), indicates that test chemical 4-chloro-1-methylpiperidinium chloride is not persistent in sediment as well.

Biodegradation in soil:

The half-life period of 4-chloro-1-methylpiperidinium chloride (CAS No: 5382 -23 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.2 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 4-chloro-1-methylpiperidinium chloride in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical 4-chloro-1-methylpiperidinium chloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water:

Predicted data for the target compound methyl chemical 4-chloro-1-methylpiperidinium chloride (CAS no. 5382 -23 -0) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:

Biodegradability of test chemical 4-chloro-1-methylpiperidinium chloride (CAS no. 5382 -23 -0) is predicted using OECD QSAR tool box v.3.3using log Kow as primary descriptor. The test chemical 4-chloro-1-methylpiperidinium chloride showed only 1 % biodegradation by BOD parameter and microorganisms as inoculum in 28 days. Since percentage of biodegradation is very less this chemical is considered as not readily biodegradable.

In another prediction done using Estimation Programs Interface Suite (EPI suite, 2017) the biodegradation potential of the test chemical 4-chloro-1-methylpiperidinium chloride (CAS No: 5382 -23 -0) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical4-chloro-1-methylpiperidinium chloride is not readily biodegradable.

In a supporting weight of evidence study from authoritative database of read across chemical chlorocyclohexane (CAS no. 542-18-7) biodegradation test was carried out by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using BOD parameter. The initial concentration of read across chemical was 100 mg/L and study design is of standard type. The percent biodegradation of read across chemical determined was 0% by BOD parameter in 14 days so it is concluded that this read across chemical is not readily biodegradable.

In another supporting weight of evidence study from authoritative database (J Check) of read across chemical 1-methyl-diethylenediamine (CAS no. 109-01-3) biodegradation test was conducted by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using O2 Consumption, DOC removal and test material analysis by HPLC parameters. The initial concentration of read across chemical was 100 mg/L. The percent biodegradation of read across chemical determined was 0% by all three parameter mentioned above in 28 days so it is concluded that read across chemical 1-methyl-diethylenediamine is not readily biodegradable.

On the basis of above results for target chemical 4-chloro-1-methylpiperidinium chloride (CAS No: 5382 -23 -0) from (EPI suite 2017 and OECD QSAR tool box v3.3 2017) and for its read across chemicals ( from authoritative database) the target chemical 4-chloro-1-methylpiperidinium chloride can be expected to be not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-chloro-1-methylpiperidinium chloride(CAS No: 5382 -23 -0) .If released in to the environment, 25.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 4-chloro-1-methylpiperidinium chloride in water is estimated to be 37.5 days (900 hrs). The half-life ( 37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 4-chloro-1-methylpiperidinium chloride in sediment is estimated to be 337.5 days (8100 hrs).  However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.154 %), indicates that test chemical 4-chloro-1-methylpiperidinium chloride is not persistent in sediment as well.

Biodegradation in soil:

The half-life period of 4-chloro-1-methylpiperidinium chloride (CAS No: 5382 -23 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74.2 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 4-chloro-1-methylpiperidinium chloride in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical 4-chloro-1-methylpiperidinium chloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.