Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-375-2 | CAS number: 5382-23-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study in Rat for CAS no: 109-01-3
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn).,2017
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of 1-Methylpiperazine was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpiperazine
- EC Number:
- 203-639-5
- EC Name:
- 1-methylpiperazine
- Cas Number:
- 109-01-3
- Molecular formula:
- C5H12N2
- IUPAC Name:
- 1-methylpiperazine
- Details on test material:
- - Name of test material: 1-Methylpiperazine
- Molecular formula: C5H12N2
- Molecular weight: 100.16 g/mol
- Substance type: Organic
- Physical state: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 1-Methylpiperazine
- Molecular formula: C5H12N2
- Molecular weight: 100.16 g/mol
- Substance type: Organic
- Physical state: No data available
- Impurities (identity and concentrations): No data available
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation:4-5 weeks
- Weight at study initiation:90-120g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): Rockland rat diet, complete.
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs): No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- 2560mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No data available- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed:no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:No data available - Statistics:
- the most probable LD,, value and its fiducial range are estimated by the method of Thompsono using the Tables of Weil
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 560 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 2560mg/kg body weight. When rats were treated with 1-Methylpiperazine (109-01-3) orally.
- Executive summary:
Acute oral toxicity study was done in5 Carworth-Wistar male rat using1-Methylpiperazine(109-01-3).All the animals having weight rang 90-120g and age 4-5 weeks and provided by Rockland rat diet, The test material in dose concentration 2560 given undiluted by oral intubation and observed for 14 days .50% mortality was observed at dose 2560mg/kg bw. HenceLD50 was considered to be2560mg/kgbody weight. When rats were treated with1-Methylpiperazine(109-01-3)orally.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
