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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute oral toxicity study in Rat for CAS no: 109-01-3
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn).,2017
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal, 1962, 23:2, 95-107

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of 1-Methylpiperazine was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 1-Methylpiperazine
- Molecular formula: C5H12N2
- Molecular weight: 100.16 g/mol
- Substance type: Organic
- Physical state: No data available
- Impurities (identity and concentrations): No data available
Specific details on test material used for the study:
- Name of test material: 1-Methylpiperazine
- Molecular formula: C5H12N2
- Molecular weight: 100.16 g/mol
- Substance type: Organic
- Physical state: No data available
- Impurities (identity and concentrations): No data available

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals and environmental conditions:
Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation:4-5 weeks
- Weight at study initiation:90-120g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): Rockland rat diet, complete.
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs): No data available

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No data available
Doses:
2560mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
No data available- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed:no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:No data available
Statistics:
the most probable LD,, value and its fiducial range are estimated by the method of Thompsono using the Tables of Weil

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 560 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be 2560mg/kg body weight. When rats were treated with 1-Methylpiperazine (109-01-3) orally.
Executive summary:

Acute oral toxicity study was done in5 Carworth-Wistar male rat using1-Methylpiperazine(109-01-3).All the animals having weight rang 90-120g and age 4-5 weeks and provided by Rockland rat diet, The test material in dose concentration 2560 given undiluted by oral intubation and observed for 14 days .50% mortality was observed at dose 2560mg/kg bw. HenceLD50 was considered to be2560mg/kgbody weight. When rats were treated with1-Methylpiperazine(109-01-3)orally.