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EC number: 945-889-4 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 September 2015 to 09 December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 10
- Temp.:
- 40 °C
- pH:
- 6.7
- Details on results:
- PRELIMINARY ESTIMATE
- The estimated Log10 Pow of the test item was calculated to be ≥ 3.32.
DEFINITIVE TEST
- Typical chromatograms are attached.
- The retention times of the dead time and the retention times, capacity factors (k') and log10 Pow values for the reference standards are shown in Tables 3.21 and 3.22 (attached).
- Retention times, capacity factors and log10 Pow values determined for the sample are shown in Table 3.23 (below). - Conclusions:
- The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0.
- Executive summary:
GUIDELINE
The determination was carried out using the HPLC Method via a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
METHOD
The test system consisted of a high performance liquid chromatograph with appropriate detectors. A reverse phase HPLC column with a very low percentage of polar groups was used.
CONCLUSION
The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0.
Reference
Table 3.23 – Partition coefficient of the sample |
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Injection |
Retention time (mins) |
Capacity factor (k’) |
Log10 k’ |
Log10 Pow |
1 |
> 70 |
> 60.1 |
> 1.78 |
> 10.0 |
2 |
> 70 |
> 60.1 |
> 1.78 |
> 10.0 |
Mean log10 Pow: > 10.0 |
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Partition coefficient: 1.0 x 1010 |
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Description of key information
The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0 (OECD 117 and EU Method A.8).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 10
- at the temperature of:
- 40 °C
Additional information
GUIDELINE
The determination was carried out using the HPLC Method via a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
METHOD
The test system consisted of a high performance liquid chromatograph with appropriate detectors. A reverse phase HPLC column with a very low percentage of polar groups was used.
CONCLUSION
The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0.
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