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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 September 2015 to 09 December 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study.
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
> 10
Temp.:
40 °C
pH:
6.7
Details on results:
PRELIMINARY ESTIMATE
- The estimated Log10 Pow of the test item was calculated to be ≥ 3.32.

DEFINITIVE TEST
- Typical chromatograms are attached.
- The retention times of the dead time and the retention times, capacity factors (k') and log10 Pow values for the reference standards are shown in Tables 3.21 and 3.22 (attached).
- Retention times, capacity factors and log10 Pow values determined for the sample are shown in Table 3.23 (below).

Table 3.23 – Partition coefficient of the sample

Injection

Retention time (mins)

Capacity factor (k’)

Log10 k’

Log10 Pow

1

> 70

> 60.1

> 1.78

> 10.0

2

> 70

> 60.1

> 1.78

> 10.0

Mean log10 Pow: > 10.0

Partition coefficient: 1.0 x 1010

Conclusions:
The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0.
Executive summary:

GUIDELINE

The determination was carried out using the HPLC Method via a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

METHOD

The test system consisted of a high performance liquid chromatograph with appropriate detectors. A reverse phase HPLC column with a very low percentage of polar groups was used.

CONCLUSION

The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0.

Description of key information

The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0 (OECD 117 and EU Method A.8).

Key value for chemical safety assessment

Log Kow (Log Pow):
10
at the temperature of:
40 °C

Additional information

GUIDELINE

The determination was carried out using the HPLC Method via a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

METHOD

The test system consisted of a high performance liquid chromatograph with appropriate detectors. A reverse phase HPLC column with a very low percentage of polar groups was used.

CONCLUSION

The partition coefficient of the test item was determined to be greater than 1.0 x 10E10 with a Log Pow of > 10.0.