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EC number: 945-889-4
CAS number: -
MEASUREMENT OF pH
- Test item undiluted as supplied.
- Aqueous preparation of test item (10 % w/w):
pH 5.8 immediately; pH 6.07 after 10 minutes.
The study was performed to assess the
irritancy potential of the test item to the eye of the New Zealand White
rabbit using a procedure designed to be compatible with OECD Guideline
for the Testing of Chemicals No 405 "Acute Eye Irritation/Corrosion"
(adopted 02 October 2012) and EU Method B.5 Acute Toxicity (Eye
Irritation) of Commission Regulation (EC) No 440/2008.
A single application of the test item to
the non-irrigated eye of two rabbits produced iridial inflammation and
moderate conjunctival irritation. Both eyes appeared normal at the 72
The test item produced a maximum group
mean score of 13.5 and was considered to be a mild irritant (Class 4 on
a 1 to 8 scale) to the rabbit eye according to a modified Kay and
Calandra system. However, the test material is not classified under the
terms of Regulation (EC) No 1272/2008
because the mean scores for two animals calculated using data from 24,
48 and 72 hour observations were below the stated limits for corneal
opacity, iritis, conjunctival redness and chemosis.
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