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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The complete read across justification is detailed in section 13. Source study has reliability 1.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method
Water solubility:
136 g/L
Temp.:
20 °C
pH:
7 - 7.1
Remarks on result:
other: ± 5 g/L
Conclusions:
Water solubility of test substance was determined to be 136 g/l at 20 °C at pH 7.
Executive summary:

Method

Test performed according to OECD guideline 105, using flask method.

Results

Water solubility = 136 g/l at 20 °C and pH 7.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
July 30, 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
not specified
Principles of method if other than guideline:
No available information on the method used.
Type of method:
flask method
Water solubility:
ca. 49.7 g/L
Temp.:
20 °C
Remarks on result:
other: no data on pH
Conclusions:
Water solubility = 49.7 g/l.
Executive summary:

Method

The test has been conducted according to EU method A.6. No other information on method is available. Information from migrated NONS file, as per Article 25(3) request, with permission to refer granted by ECHA.

Results

Water solubility = 49.7 g/l.

Description of key information

Very soluble in water.

Key value for chemical safety assessment

Additional information

No data on test substance itself was available. A weight of evidence approach was adopted, using Similar Substance 01 and 02 as read across substances. In particular, Similar Substance 01 is an isomer of test substance, differing only for the position of one functional group on an aromatic ring; Similar Substance 02 has structural similarity with test susbtance. A detailed justification of the read across process is attached in section 13.

Based on migrated information from NONS file, as per Article 25(3) request, Similar Substance 01 has water solubility = 49.7 g/l. Permission to refer is granted by ECHA.

As for Similar Substance 02, water solubility at 20 °C and pH 7 is 136 g/l.

Overall, based on available data, test item is expected to be very soluble, above 10 g/l at 20 °C.