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Administrative data

Description of key information

LD50 (oral) = 4028 mg/kg
LD50 (dermal) > 2000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact the acute toxicity potential. Source study has reliability 2: only limited information available from a migrated NONS file, as per Article 25(3) request.
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
No information on the method is available
GLP compliance:
yes
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 4 028 mg/kg bw
Based on:
not specified
Interpretation of results:
other: not classified according to the CLP Regulation (EC 1272/2008)
Conclusions:
LD50 = 4028 mg/kg bw
Executive summary:

Method

Test conducted according to OECD guideline 401. No details on method are available. Information from migrated NONS file, as per Article 25(3) request; permission to refer is granted by ECHA.

 

Results

LD50 = 4028 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
4 028 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact the acute toxicity potential. Source study has reliability 2: only limited information available from a migrated NONS file, as per Article 25(3) request.
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
No information on the method is available
GLP compliance:
yes
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
not specified

Route of administration: percutaneous.

Interpretation of results:
other: not classified according to the CLP Regulation (EC 1272/2008)
Conclusions:
LD50 > 2000 mg/kg bw.
Executive summary:

Method

Test conducted according to OECD guideline 402. No details on method are available. Information from migrated NONS file, as per Article 25(3) request; permission to refer is granted by ECHA.

 

Results

LD50 > 2000 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Acute toxicity: oral

A test was conducted according to OECD guideline 401. Using Similar Substance 01, an LD50 of 4028 mg/kg bw was found.

Acute toxicity: dermal

A test was conducted according to OECD guideline 402. Similar Substance 01 showed an LD50 higher than 2000 mg/kg bw for acute dermal toxicity.

Justification for classification or non-classification

A classification for acute toxicity does not apply to the substance.