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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact the irritation potential. Source study has reliability 2: only limited information available from a migrated NONS file, as per Article 25(3) request.

Data source

Reference
Reference Type:
other: information from migrated NONS file, as per Article 25(3) request, permission to refer granted by ECHA
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Similar Substance 01
IUPAC Name:
Similar Substance 01
Test material form:
solid

Results and discussion

In vivo

Results
Remarks on result:
other: lack of details; data from migrated NONS file

Any other information on results incl. tables

Moderate conjunctival response with chemosis noted at 1 hour and redness at 24 hours. By 72 hours only slight conjunctival redness in one animal. The substance is not classifiable as an eye irritant.

Applicant's summary and conclusion

Interpretation of results:
other: not classified according to the CLP Regulation (EC 1272/2008)
Conclusions:
Not irritant.
Executive summary:

Method

Test conducted according to OECD guideline 405. No details are available. Information derived from migrated NONS file, as per Article 25(3) request with permission to refer granted by ECHA.

Results

Moderate conjunctival response with chemosis noted at 1 hour and redness at 24 hours. By 72 hours only slight conjunctival redness in one animal.

Not irritant.