Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact the toxicity potential. Source study has reliability 4: only limited information available from a migrated NONS file, as per Article 25(3) request.

Data source

Reference
Reference Type:
other: information from migrated NONS file, as per Article 25(3) request, permission to refer granted by ECHA
Title:
Unnamed
Year:
1985

Materials and methods

Principles of method if other than guideline:
No information on the method is available.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Similar Substance 01
IUPAC Name:
Similar Substance 01
Test material form:
solid

Administration / exposure

Duration of treatment / exposure:
28 days

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
ca. 1 000 mg/kg bw/day (nominal)
Based on:
not specified
Sex:
not specified
Basis for effect level:
other: not specified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
NOAEL = ca. 1000 mg/kg bw/day
Executive summary:

Method

No information on the method is available. Information derived from migrated NONS file, as per Article 25(3) request, permission to refer granted by ECHA.

 

Results

NOAEL = ca. 1000 mg/kg bw.