Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-117-5 | CAS number: 302-17-0
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
At an initial concentration of 88 and 84.8 uM hydrolysis rate constants for chloral hydrate was determined to be 1.0X10-3/hr and 1.8X10-3/hr using MOPS buffer and carbonate buffers respectively in the presence of carbonate green rust; GR(CO32-).
Chloral hydrate were transformed via parallel pathways of hydrolysis and sequential hydrogenolysis in the presence of GR(CO32-).
Chloral hydarte was degraded to TCM (Tricholormethane) via hydrolysis (31%) and to DCAh (Dichloro acetaldehyde hydrate) via hydrogenolysis (69%).
Additional information
Hydrolysis:
The study was performed to investigate the kinetics and pathways of the degradation of selected halogenated DBPs (Disinfection byproducts), i.e. cholral hydrate in the presence of carbonate green rust; GR(CO32-). DBP degradation experiments were carried out in 123 mL serum bottles containing a 2.4 g/L GR(CO32-) suspension buffered at pH 7.5 with Ar-sparged 25 mM MOPS buffer or 50 mM carbonate buffer at 22±3 °C. All batch experiments were conducted in duplicate. The overall loss and individual hydrolysis and reductive dehalogenation pseudo-first-order rate constants of the DBPs were determined by fitting the experimental data using Scientist for Windows (v. 2.01, Micromath Research).
At an initial concentration of 88 and 84.8 uM hydrolysis rate constants for chloral hydrate was determined to be 1.0X10-3/hr and 1.8X10-3/hr using MOPS buffer and carbonate buffers respectively in the presence of GR(CO32-). Chloral hydrate were transformed via parallel pathways of hydrolysis and sequential hydrogenolysis in the presence of GR(CO32-). Chloral hydarte was degraded to TCM (Tricholormethane) via hydrolysis (31%) and to DCAh (Dichloro acetaldehyde hydrate) via hydrogenolysis (69%).
Thus, from above study it can be considered that the substance chloral hydrate is very slowly hydrolysable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
