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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative review article and database.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
CONCISE INTERNATIONAL CHEMICAL ASSESSMENT DOCUMENT NO. 25; CHLORAL HYDRATE
Author:
World Health Organisation
Year:
2000
Bibliographic source:
International Programme on Chemical Safety, Environmental Health Criteria (EHS)
Reference Type:
other: Authoritative database
Title:
Acute inhalation toxicity value for CAS 302-17-0
Author:
IFA-Gestis
Year:
2018
Bibliographic source:
Gestis substance database

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity was determined for the test substance 2,2,2-trichloroethane-1,1-diol (Chloral hydrate) in mice following 6 hour exposure.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
100 ppm (20mg/Kg bw)
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 603 mg/m³ air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: Following cessation of exposure, the animals regained consciousness.
Mortality:
no mortality observed
Clinical signs:
other: Clinical Signs observed were Deep narcosis, following effects were induced in the lung: formation of vacuoles in the Clara cells, scaling off of the epithelium and pulmonary edema (increase of the lung weight by a factor of 1.5).
Body weight:
not specified
Gross pathology:
not specified
Other findings:
Following cessation of exposure, the animals regained consciousness.

Applicant's summary and conclusion

Interpretation of results:
other: not toxic
Conclusions:
The LC50 for the given test material Chloral Hydrate is found to be >100 ppm (>603mg/m3).
Executive summary:

Mice were exposed to the test material chloral hydrate at a concentration of 100 ppm ( 603mg/m3) for 6 hours. 

Inhalation exposure resulted in deep narcosis but following cessation of exposure, the animals regained consciousness. The following effects were induced in the lung: formation of vacuoles in the Clara cells, scaling off of the epithelium and pulmonary edema (increase of the lung weight by a factor of 1.5).

Acute inhalation study conducted shows that the LC50 for the given test material Chloral Hydrate is found to be >100 ppm (>603 mg/m3).

This value indicates thta the substance is not toxic via inhalation route and thus considered as Not classified for Acute toxicity inhalataion as per CLP classification criteria.