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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Gestis database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
Acute dermal toxicity value for CAS No. 302-17-0
Author:
IFA-Gestis
Year:
2018
Bibliographic source:
Gestis substance database

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate the acute dermal toxicity of Chloral hydrate in rats.
GLP compliance:
not specified
Test type:
other: not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specifiednot specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 030 mg/kg bw
Based on:
test mat.
Mortality:
Yes, 50% mortality observed at 3030 mg/kg dose
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: not toxic
Conclusions:
The acute dermal LD50 value of the substance Chloral Hydrate was determined to be 3030 mg/kg bw for rats.
Executive summary:

The acute dermal toxicity of Chloral hydrate in rats was evaluated.50% mortality was observed at 3030 mg/kg dose. Hence the acute dermal LD50 value of the substance Chloral Hydrate was determined to be3030 mg/kg bw for rats.

This value indicates that the substance is not toxic via dermal route of exposure and hence is considered as Not classified for acute dermal toxicity as per CLP classification criteria.