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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Acute toxicity
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Although cited in several government and non-governmental publications, no primary source has been found
The oldest reference is found in 'Agrochemicals Handbook, Hartley and Kidd, eds.,Royal Soc. of Chemistry, 1983-86'
There is no justification to perform further animal tests.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Guideline not specified.
Performed prior to 1983
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,2-trichloroethane-1,1-diol
EC Number:
206-117-5
EC Name:
2,2,2-trichloroethane-1,1-diol
Cas Number:
302-17-0
Molecular formula:
C2H3Cl3O2
IUPAC Name:
2,2,2-trichloroethane-1,1-diol
Test material form:
solid: granular

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 3 030 mg/kg bw
Based on:
test mat.
Mortality:
Not specified
Clinical signs:
Not specified
Body weight:
Not specified
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Although no primary reference was located, many reliable data sets have used this figure for acute dermal LD50
There is no justification to perform further animal tests.