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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Eye Irritation data for chloral hydarate
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Chloral hydrate eye irritation data from HSDB database
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:
other: not specified
Strain:
not specified
Details on test animals or tissues and environmental conditions:
not specified

Test system

Vehicle:
not specified
Amount / concentration applied:
not specified
Duration of treatment / exposure:
not specified
Observation period (in vivo):
not specified
Duration of post- treatment incubation (in vitro):
not specified
Number of animals or in vitro replicates:
not specifiednot specified
Details on study design:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
other: Moderate doses affects eye movements, particularly interfering with convergence, and sometimes causing ptosis. It may cause swelling of lids, hyperemia and edema of the conjunctivae, plus a sensation of irritation and tearing.
Irritant / corrosive response data:
Moderate doses affects eye movements, particularly interfering with convergence, and sometimes causing ptosis. It may cause swelling of lids, hyperemia and edema of the conjunctivae, plus a sensation of irritation and tearing.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Moderate dose of chloral hydrate is found to irritating to the eye.
Executive summary:

Moderate doses of chloral hydrate affects eye movements, particularly interfering with convergence, and sometimes causing ptosis. It may cause swelling of lids, hyperemia and edema of the conjunctivae, plus a sensation of irritation and tearing. GHS classification of the substance also indicates the substance to be irritating to eye and hence classified as Eye irritant 2.