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Density

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Reference
Endpoint:
density, other
Remarks:
pour density; tap density
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
GLP compliance:
no
Type of method:
other: pour and tap density method
Specific details on test material used for the study:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid
Key result
Type:
pour density
Density:
0.947 g/cm³
Temp.:
28.9 °C
Remarks on result:
other: Atmospheric pressure = 974.5hPa
Key result
Type:
tap density
Density:
0.967 g/cm³
Temp.:
28.9 °C
Remarks on result:
other: Atmospheric pressure = 974.5hPa

Observations:

Method Details

Observations

Remarks if, any

Guideline

OECD 109

1stReading

2ndReading

 

 

 

Method

Test methods: Pour density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1]

 

 

 

Principle of method

The density is calculated from the difference in weight between the full and empty pycnometer and its volume.

 

 

 

 

Test temperature (°C)

-

29°C

28.9°C

 

Atmospheric pressure (in hPa)

-

974.5 hPa

974.6 hPa

 

Volume of test substance without tapping (V)

 

19.5 ml

23 ml

 

Volume of test substance after tapping (V1)

 

19.5 ml

22 ml

 


[1]The International Pharmacopoeiahttp://apps.who.int/phint/en/p/docf/anchor,get-started.html

CALCULATIONS:

Parameters

Details

Calculated values

Average Density

1st Calculation

2ndCalculation

Pour Density of test substance (g/cm3)

m
    v

1.025

0.8695

0.9472

Tap density of test substance (g/cm3)

m
    v1

1.025

0.9090

0.9670

 

Conclusions:
The pour density and tapped density of 2,2,2-trichloroethane-1,1-diol CAS No. 302-17-0 was found to be 0.9472 g/cm3 and 0.9670 g/cm3 at 28.9 °C and 974.5hPa respectively.

Executive summary:

The density of test substance 2,2,2-trichloroethane-1,1-diol (CAS No. 302-17-0 ) was determined following OECD guideline 109 according to pour and tap density method. The pour density and tapped density of the test substance was found to be0.9472 gm/cm3and 0.9670 gm/cm3at 28.9 °C and 974.5 hPa.

Description of key information

The density of test substance 2,2,2-trichloroethane-1,1-diol (CAS No. 302-17-0 ) was determined following OECD guideline 109 according to pour and tap density method. The pour density and tapped density of the test substance was found to be 0.9472 g/cm3 and 0.9670 g/cm3 at 28.9 °C and 974.5 hPa. The value of density for chemical safety assessment was considered to be 0.9472 g/cm3

Key value for chemical safety assessment

Relative density at 20C:
0.947

Additional information

The density of test substance 2,2,2-trichloroethane-1,1-diol (CAS No. 302-17-0 ) was determined following OECD guideline 109 according to pour and tap density method. The pour density and tapped density of the test substance was found to be0.9472 g/cm3and 0.9670 g/cm3at 28.9 °C and 974.5 hPa.