Registration Dossier
Registration Dossier
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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
The skin sensitization was analyzed in a study performed under GLP according to OECD guideline 406, where twenty Dunkin-Hartley Guinea pigs were induced intradermally with a concentration of 0.5% and and topically with a concentration of 50%, respectively. The first challenge was done topically with a concentration of 10% on day 22, while a concentration of 50% for the second challenge was used. As result, 8 of 20 animals showed a sensitizing reaction. Thus, the frequency of animals responding positively exceeds 30% and the test substance was found to be sensitizing to skin.
Migrated from Short description of key information:
Vanadyl pyrophosphate was found to be a skin sensitiser.
Justification for classification or non-classification
Based on the available data, the substance vanadyl pyrophosphate needs to be classified:
DSD: sensitizing, R43CLP: sensitisation category 1
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