Registration Dossier
Registration Dossier
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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
Endpoint summary
Administrative data
Description of key information
- oral: LD50 (rat) = 2171 mg/kg bw
- dermal: LD50 (rat) > 2000 mg/kg bw
Key value for chemical safety assessment
Additional information
Oral
The acute oral toxicity was evaluated in study performed under GLP according to OECD guideline 401. Five male and female Crj: CD(SD) rats were treated with a suspension containing a concentration of up to 5000 mg/kg bw. The observed clinical signs included signs of comprised lethargy, decreased motor activity, prone posture, ataxia and muscle tremor, as well as bradypnoea, hyperpnoea and piloerection. Based on the observed moratlity, the oral LD50 was found to be 2171 mg/kg bw for male and female rats.
Dermal
The acute dermal toxicity study was performed under GLP according to OECD guideline 402. Five male and female Crj: CD(SD) rats were exposed to the test substance in a concentration of 2000 mg/kg (limit test) under occlusive conditions for 24 hours. Since no mortality was observed, the LD50 was found to be >2000 mg/kg bw.
Justification for classification or non-classification
The available data on vanadyl pyrophosphate are conclusive but not sufficient for classification according to EU and GHS criteria.
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