Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Assessed after consultation with the relevant Authority. Data migrated from NONS files provided by Authority contain insufficient information.

Data source

Reference
Reference Type:
other: no data
Title:
Unnamed
Report date:
1991

Materials and methods

Principles of method if other than guideline:
Chromosome aberration in vivo
GLP compliance:
not specified
Type of assay:
other: Non-bacteriological test in vivo - 6th amendment data

Test material

Constituent 1
Chemical structure
Reference substance name:
Vanadyl pyrophosphate
EC Number:
406-260-5
EC Name:
Vanadyl pyrophosphate
Cas Number:
58834-75-6
Molecular formula:
O9P2V2
IUPAC Name:
vanadyl pyrophosphate
Details on test material:
- Analytical purity: no data

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
500, 1000, 2000 mg/kg
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative