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EC number: 406-260-5
CAS number: 58834-75-6
BTN; VPO CATALYST
There are no reliable data for vanadyl pyrophosohate. Thus
read-across was performed with the structurally similar substance,
vanadium oxide sulphate (CAS 27774-13-6).
In a published study, a group of seven male rats were dosed with
100 mg/kg bw/d via drinking water. During the five last days of the
treatment period, they were cohabited with pro-estrus females. The males
were sacrificed on day 61 and the testes and accessory organs were
examined, while the successfully mated females were allowed to litter.
As results, changes in the weight and the biochemical parameters of
reproductive organs were noted and differences in morphometry of
reproductive organ tissue were found. The sperm motility and density was
reduced, resulting in the found decline in fertility and litter size.
However, no effects via lactation were reported. Based on these
findings, the LOAEL for male fertility was 100 mg/kg bw/d. Due to the
structural similarity of vanadyl pyrophosphate and vanadium oxide
sulphate, the same results can be expected for vanadyl pyrophosphate
with a corresponding dose of 189 mg/kg bw/d.
Based on the vailable data, vanadyl pyrophosphate needs to be classified:
CLP: reproductive toxicity category 2
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