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Key value for chemical safety assessment

Effects on fertility

Additional information

There are no reliable data for vanadyl pyrophosohate. Thus read-across was performed with the structurally similar substance, vanadium oxide sulphate (CAS 27774-13-6).

In a published study, a group of seven male rats were dosed with 100 mg/kg bw/d via drinking water. During the five last days of the treatment period, they were cohabited with pro-estrus females. The males were sacrificed on day 61 and the testes and accessory organs were examined, while the successfully mated females were allowed to litter. As results, changes in the weight and the biochemical parameters of reproductive organs were noted and differences in morphometry of reproductive organ tissue were found. The sperm motility and density was reduced, resulting in the found decline in fertility and litter size.

However, no effects via lactation were reported. Based on these findings, the LOAEL for male fertility was 100 mg/kg bw/d. Due to the structural similarity of vanadyl pyrophosphate and vanadium oxide sulphate, the same results can be expected for vanadyl pyrophosphate with a corresponding dose of 189 mg/kg bw/d.

Short description of key information:
- oral: LOAEL (rat) = 189 mg/kg bw/d

Justification for classification or non-classification

Based on the vailable data, vanadyl pyrophosphate needs to be classified:

EU: R62

CLP: reproductive toxicity category 2

Additional information