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EC number: 406-260-5
CAS number: 58834-75-6
BTN; VPO CATALYST
Genetic toxicity was evaluated in a bacterial reverse mutation assay
performed under GLP according to OECD guideline 471. Bacteria strains
TA98, TA1535, TA1538, TA100 and TA1537 were treated with concentrations
up to 2500 μg/plate with and without Aroclor 1254 induced rat S-9 liver
enzyme mix. As result, vanadyl pyrophosphate was not mutagenic under the
conditions of test.
Genetic toxicity in mammalian cells was analyzed in a mammalian
chromosome aberration test which was performed under GLP according to
OECD guideline 473. BTN/A treated human lymphocyte cultures treated with
40 μg/mL without metabolic activation and treated with a concentration
of 200 μg/mL with metabolic activation by Aroclor 1254 induced rat S-9
liver enzyme mix showed several cases of chromatid separation. Although
this effect was more pronounced at the higher concentration of vanadyl
pyrophosphate used in the preliminary study, this effect is believed to
indicate a non-specific effect on chromosome morphology. However, as
this is not an indicator of clastogenic activity of the test material,
no mutagenicity was found.
Due to the lack of an in vtro mutagenicity study, a published study with
the structural analogue vanadium oxide sulphate was used for read-across
(Galli et al., 1991). As result, no gene mutation in the HPRT locus of
V79 cells was found when the cells were treated with concentrations of
1, 2, 5 and 7.5 mM with and without metabolic activation by mouse
hepatic S-9 mix.
The in vivo exposure of male and female CD-1 mice with oral doses of
500, 1000, 2000 mg/kg did not induce chromosome aberrations.
The available data on genetic toxicity in
vitro and in vivo are conclusive but not sufficient for classification.
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