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EC number: 406-260-5
CAS number: 58834-75-6
BTN; VPO CATALYST
Vanadyl pyrophosphate is not irritating to the skin but is an eye irritant.
Irritation of the skin was evaluated in a study performed under
GLP according to OECD guideline 404. Three New Zealand White rabbits
were treted with 0.5 g of the test substance under semiocclusive
conditions for 4 hours and observed for 14 days. The resulting mean
scores for edema and erythema from 24 to 72 h were both 0, respectively.
Thus, the test material showed no skin irritation.
The acute eye irritation was analyzed in a study performed under
GLP according to OECD guideline 405. 100 mg of the the test substance
was instilled into the eyes of 3 New Zealand White rabbits and reactions
were observed up to 15 days. The resulting mean scores after 24 to 72
hours for cornea, iris and conjunctival erythema and chemosis were found
to be 0.4, 0.4, 1.9 and 1.0, respectively. However, due to severe
irritation effects observed in one animal, this animal was sacrified
prior to scheduled study end. Therefore, the test substance was
calssified to be an eye irritant.
The available data on vanadyl pyrophosphate
are conclusive but not sufficient for classification.
Based on the available data, the substance
vanadyl pyrophosphate needs to be classified:
CLP: eye irritation, category 2
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