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Diss Factsheets

Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study following principles equivalent to those given in OECD TG 104 (gas saturation method)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
yes
Remarks:
Filtered air was used instead of inert carrier gas
GLP compliance:
no
Type of method:
gas saturation method
Key result
Temp.:
25 °C
Vapour pressure:
0.01 Pa
Remarks on result:
other: Average of nine measurements
Conclusions:
The substance has a vapour pressure of 0.0104 Pa at 25 °C.
Executive summary:

The vapour pressure of the test substance Benzyl salicylate was determined in a non-GLP experiment following to a large extent the principles of the gas saturation method described in OECD TG 104. A defined amount of test material was filled into a closed vessel and a headspace was allowed. The vessel was placed in a water bath and kept at a constant temperature until an equilibrium between the test material and the gas phase was achieved. Subsequently, air was slowly drawn from the headspace at a constant flow rate (normally between 5 to 8 mL/min) and replaced with air filtered through active carbon. For substances with vapour pressures below 0.1 Pa, a total sample volume of 1000 mL is normally used. The sampled headspace air containing the test substance was then led through an absorbent material (Porapak Q) to trap the test substance. The test substance was extracted from the absorbent by use of an appropriate solvent. The amount of trapped substance was determined by gas chromatography and the vapour pressure was calculated by using the equation ps = (ms x R x T)/(M x V). The measured vapour pressure of Benzyl salicylate was 0.0104 Pa at 25 °C (mean of nine measurements) and the relative standard deviation was 2.48%.

Description of key information

The vapour pressure was determined to be 0.0104Pa at 25°C.

Key value for chemical safety assessment

Vapour pressure:
0.01 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the test substance Benzyl salicylate was determined in a non-GLP experiment following to a large extent the principles of the gas saturation method described in OECD TG 104. A defined amount of test material was filled into a closed vessel and a headspace was allowed. The vessel was placed in a water bath and kept at a constant temperature until an equilibrium between the test material and the gas phase was achieved. Subsequently, air was slowly drawn from the headspace at a constant flow rate (normally between 5 to 8 mL/min) and replaced with air filtered through active carbon. For substances with vapour pressures below 0.1 Pa, a total sample volume of 1000 mL is normally used. The sampled headspace air containing the test substance was then led through an absorbent material (Porapak Q) to trap the test substance. The test substance was extracted from the absorbent by use of an appropriate solvent. The amount of trapped substance was determined by gas chromatography and the vapour pressure was calculated by using the equation ps = (ms x R x T)/(M x V). The measured vapour pressure of Benzyl salicylate was 0.0104 Pa at 25 °C (mean of nine measurements) and the relative standard deviation was 2.48%.