Registration Dossier
Registration Dossier
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EC number: 203-742-5 | CAS number: 110-16-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology of the eye
- Author:
- Grant J (ed)
- Year:
- 1 986
- Bibliographic source:
- In: Toxicology of the eye, 3rd ed., 574. Springfield, IL: Charles C. Thomas
- Reference Type:
- review article or handbook
- Title:
- Final report on the Safety Assessment of Maleic Acid
- Author:
- American College of Toxicology
- Year:
- 2 007
- Bibliographic source:
- International Journal of Toxicology 26, 125-130
Materials and methods
Test material
- Reference substance name:
- Maleic acid
- EC Number:
- 203-742-5
- EC Name:
- Maleic acid
- Cas Number:
- 110-16-7
- Molecular formula:
- C4H4O4
- IUPAC Name:
- but-2-enedioic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- 10 % to 1 %
- Duration of treatment / exposure:
- 30 sec (10 %) to 2 min (1 %)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: permanent corneal opacity and vascularization
- Basis:
- other: no data
- Remarks on result:
- other: test substance concentration 10 %, pH 1.0
- Irritation parameter:
- other: transient corneal cloudiness
- Basis:
- other: no data
- Remarks on result:
- other: test substance concentration 1 %, pH 1.0
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In the eyes of rabbits, maleic acid caused permanent corneal opacity and vascularization at a concentration of 10% (pH= 1.0) after 30 seconds, and transient corneal cloudiness at a concentration of 1 % (pH = 1.0) after 2 minutes.
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