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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Maleic anhydride
EC Number:
203-571-6
EC Name:
Maleic anhydride
Cas Number:
108-31-6
Molecular formula:
C4H2O3
IUPAC Name:
furan-2,5-dione
Details on test material:
See also SIDS Initial Assessment.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
1 h
Concentrations:
0.72 mg/L
No. of animals per sex per dose:
6 rats in total

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 0.72 mg/L air
Mortality:
No mortality occurred.
Clinical signs:
other: Generalized inactivity, hyperpnea, sedation within 15 minutes of exposure
Gross pathology:
No significant findings

Applicant's summary and conclusion

Conclusions:
The LC50 was >0.72 mg/L air for rats exposed to the maleic acid for 1 hour.