Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Two studies on skin sensitisation are available for maleic acid. Maleic acid was sensitising in a guinea pig maximisation test as well as in a local lymph node assay.

Migrated from Short description of key information:
Weber 2004, LLNA, OECD 429: sensitising
Weiss 2002, GPMT, OECD 406: sensitising

Justification for classification or non-classification

According to the results of the studies available maleic acid has to be classified as "R43 May cause sensitisation by skin contact" / "Skin sensitisation Category 1".