Registration Dossier

Toxicological information

Carcinogenicity

Currently viewing:

Administrative data

Endpoint:
carcinogenicity
Remarks:
intratracheal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Document is a review of over 250 substances and their potential to cause lung tumors in primates and rodents. Several different study methods, species types and test types were reviewed. Results were recorded in table format and no conclusion on the potential for tungsten carbide to cause lung tumors was reported.

Data source

Reference
Reference Type:
publication
Title:
Lung Tumors of Primates and Rodents.
Author:
Schepers GWH.
Year:
1971
Bibliographic source:
Industrial Medicine & Surgery 40: 48-53.

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
intratracheal
Vehicle:
not specified
Details on exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
12 months
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Positive control:
no

Examinations

Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Histopathological findings: neoplastic:
not specified
Details on results:
- Test animals reported slight reaction to epithelialization and other lesions. Animals reported a slight reaction to test substance. No further details were provided.
- No neoplasia was indicated for tungsten carbide

Applicant's summary and conclusion