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EC number: 235-123-0 | CAS number: 12070-12-1
In a semi-occlusive skin irritation study conducted on rabbits according to OECD 404, WC elicited no dermal irritation. In an eye irritation study conducted on rabbits according to OECD 405, instillation of WC into the rabbit elicited transient very slight to well-defined conjunctival irritation only. Based on the results of this study, WC can be considered as non-irritant.
A skin irritation study of sufficient quality and tested in accordance with standard methodology showed that WC was not irritating to skin. Therefore, no classification is required for the skin irritation endpoint for WC.
In an eye irritation study of sufficient quality and conducted in accordance with standard methodology, the mean scores for all 3 animals were zero for the cornea and iris. In 2 of the 3 animals, the average score for conjunctival redness over 24, 48, and 72 hours was 0.3. The conjunctival redness reported in these 2 animals was only observed at 24 hours and was fully reversible by 48 hours. The average score at 24, 48, and 72 hours for the remaining rabbit was zero for conjunctival effects. The cutoff value for eye irritation classification is a positive response of corneal opacity ≥ 3 and/or iritis > 1.5 calculated as the mean scores following grading at 24, 48, and 72 hours after installation of the test material. Therefore, no classification is required for the eye irritation endpoint for WC.
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