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Description of key information

In a semi-occlusive skin irritation study conducted on rabbits according to OECD 404, tungsten carbide (WC) elicited no dermal irritation. In an eye irritation study conducted on rabbits according to OECD 405, instillation of WC into the rabbit elicited transient very slight to well-defined conjunctival irritation only. Based on the results of this study, WC can be considered as non-irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Justification for type of information:
Data waiving
Reason: Study scientifically not necessary
Justification: An in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
Justification for type of information:
Data waiving
Reason: Stucy scientifically not necessary
Justification: An in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available,
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

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