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Long-term toxicity to aquatic invertebrates

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Description of key information

22-d NOEC (reproduction)  = 3.64 mg/L

Based on the GHS, no chronic toxicity is anticipated at an NOEC or EC10 > 1 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
3.64 mg/L

Additional information

The chronic toxicity of 3 -aminopropyldimethylamine was assessed in a semi-static 22-d reproduction test according to OECD 211, using Daphnia magna as test species. The test substance concentrations were analytically verified. The initial test concentrations and those after 48 and 72 hours of exposure deviated less than 20% from the nominal concentrations, except for samples of one test concentration on day 19, which deviated more than 20% from the nominal concentration. Therefore, the results are based on time-weighted average concentrations. All validity criteria were fulfilled. After 22 days, a NOEC (reproduction) of 3.64 mg/L was determined, based on time-weighted average concentrations (BASF SE, 2017, report no.: 51E0340/15E017).

In addition, the long-term effect was estimated using the estimation model ECOSAR v1.11 implemented in EPISuite v4.11; a chronic value of 4.5 mg/L was calculated. The substance was within the applicability domain, but as long-term prediction by the model has been developed based on a small data pool (training set: n < 5), the modeled results have a high uncertainty. Therefore, the results of this QSAR model are disregarded.

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