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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

Depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible.

Key value for chemical safety assessment

EC50 for microorganisms:
94.5 mg/L
EC10 or NOEC for microorganisms:
69.5 mg/L

Additional information

In order to assess the toxicity of 3 -aminopropyldimethylamine (DMAPA) to microorganisms there are experimental data for the target item as well as for the structural analogous substance 3 -aminopropyldiethylamine (DEAPA; CAS 104 -78 -9) available:

As key study a non-GLP test according to German Industrial Standard DIN 38412 was performed with DMAPA using Pseudomonas putida as test organism. The stability of the target item 3-Aminopropyldimethylamine (CAS 109-55-7) in the test medium has not been analytically verified, but is considered to be stable due to the high water solubility (WS = 1E+06 mg/L), the moderate vapour pressure (VP = 5.9 hPa, at 20 °C) and the low Henry´s law constant (HLC, uncharged: 6.71E-04 Pa*m3/mol) of the substance. The EC10 (17h) was estimated to be 69.5 mg/L and the EC50 94.5 mg/L, both related to the nominal concentrations.

The data for the target item are supported by the results of a study conducted according to OECD 209 with the structural analogue DEAPA. The 30 -min EC20 was determined to be > 1000 mg/L, indicating that no effect on the degradation activity is anticipated for activated sludge if the analogue DEAPA is introduced in appropriately low concentrations. The concentrations were not analytically verified during the test but DEAPA is expected to be stable in water due to it's physico-chemical properties comparable to the ones of target item as the substance is miscible in water, its vapor pressure is moderate and its Henry's law constant is low.