Registration Dossier
Registration Dossier
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EC number: 233-113-0 | CAS number: 10035-10-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No data available on HBr. Mutagenicity data available on two analogue substances, PBr3 (which hydrolyses to HBr and phosphonic acid) and HCl. (Read-across justifications in Section 8.6 Repeat dose toxicity). Read-across to these substances, in particular HCl which displays the same chemical characteristics as HBr indicates that the pH of the substance can produce false positive results in vitro at levels that are cytotoxic. As HBr is a stronger acid than HCl (See Section 8.8.1 Toxicokinetics Assessment), it can be assumed that cytotoxicty would occur at lower or equivalent dose levels to HCl. It is therefore considered that the mutagenic potential of HBr is similar or equivalent to that of HCl. HCl is not considered to be mutagenic in vitro.
In vitro
Mattie, D.R., et al., (1996) on PBr3 remarks that genotoxicity testing of bacterial Salmonella strains indicated that PBr3 is not a mutagen for both frame shift and base-pair substitution tester strains in both buffered and unbuffered solutions. PBr3 reacts with moisture to form HBr and phosphonic acid. Thus, it is not likely that HBr is a bacterial mutagen.
The International Programme on Chemical Safety (IPCS) (2002) and the OECD Screening Information Data Sets (SIDS) for HCl summarise that HCl would not be expected to react with DNA.
A number of studies have been carried out to assess the mutagenicity of hydrogen chloride. Negative results were obtained for the Ames test, as well as for a mitotic recombination test using S. Cerevisiaeand Rec asay using E. coli.
HCl-induced chromosomal aberrations were reported in Chinese hamster ovary cells and in the mammalian cell gene mutation assay using mouse lymphoma L5178Y cells. However such positive results were observed at cytotoxic conditions and thought to be artefacts due to low pH. Positive results were reported in a Sex Linked Recessive Lethal assay with D. melanogaster.
No mammalianin vivostudies were available
Overall, it was assumed that HCl does not have any significant mutagenic potential.
By comparison to HCl, HBr is not considered to be mutagenic in vitro.
Short description of key information:
No data available on hydrogen bromide (HBr). Mutagenicity data available on two analogue substances, PBr3 which hydrolyses to HBr and phosphonic acid and hydrogen chloride (HCl) (Read-across justifications in Section 8.6 Repeat dose toxicity). Read-across to these substances, in particular HCl which displays the same chemical characteristics as HBr indicates that the pH of the substance can produce false positive results in vitro at levels that are cytotoxic. As HBr is a stronger acid than HCl (See Section 8.8.1 Toxicokinetics Assessment), it can be assumed that cytotoxicity would occur at lower or equivalent dose levels to HCl. It is therefore considered that the mutagenic potential of HBr is similar or equivalent to that of HCl. Since HCl is not considered mutagenic, HBr is not considered to be mutagenic in vitro.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
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