Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical observation
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Clinical case study.

Data source

Reference
Reference Type:
publication
Title:
Chemical Pneumonitis Due to Exposure to Bromine Compounds
Author:
Kraut, A., and Lilis, R.
Year:
1988
Bibliographic source:
Chest, Vol. 94, Iss. 1, pp. 208-210

Materials and methods

Study type:
poisoning incident

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrogen bromide
EC Number:
233-113-0
EC Name:
Hydrogen bromide
Cas Number:
10035-10-6
Molecular formula:
BrH
IUPAC Name:
hydrogen bromide

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 1
- Sex: Male
- Age: 60 years old
-
- Other: Laboratory Technician
Ethical approval:
not applicable
Route of exposure:
inhalation
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified
Details on exposure:
Accidental exposure to mixture of hydrogen bromide (HBr) and phosphorus tribromide (PBr3). Pulmonary infiltrates developed consistent with chemical pneumonities, which developed into a protracted illness.

Results and discussion

Results of examinations:
Chest x-rays led to diagnosis of chemical pneumonitis. Pulmonary infiltrates did not completely resolve. Relapses occurred at 1 and 3 months, and also at 7 months when possible exposed to other respiratory irritants. Chest x-rays had normalized at 10 months after exposure, but transbronchial biopsy showed a diffusion abnormality consistent with interstitial pulmonary fibrosis. The recurrence of respiratory symptoms and pulmonary infiltrates without documented resolution suggested bronchiolitis obliterans.
Effectivity of medical treatment:
Though respiratory symptoms resolved initially, relapses occurred at 1, 3 and 7 months. At 10 months, the chest X-rays showed normalization, but a transbronchial biopsy showed interstitial pulmonary fibrosis. History and pathology were consistent with bronchiolitis obliterans, a potentially fatal complication of toxic irritant gas exposure.

Applicant's summary and conclusion

Conclusions:
Accidental exposure to vapors from a mixture of HBr and PBr3 caused chemical pneumonitis, and a protracted illness. Transbronchial biopsy at 10 months showed fibrosis consistent with bronchiolitis obliterans, a potentially fatal complication of toxic irritant gas exposure.
Executive summary:

Accidental exposure to vapors from a mixture of HBr and PBr3 caused chemical pneumonitis, and a protracted illness. Transbronchial biopsy at 10 months showed fibrosis consistent with bronchiolitis obliterans, a potentially fatal complication of toxic irritant gas exposure.