Registration Dossier
Registration Dossier
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EC number: 233-113-0 | CAS number: 10035-10-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result is considered to be reliable for determination of classification.
Data source
Reference
- Reference Type:
- publication
- Title:
- I. Experimental study - Cutaneous burns in rats induced by hydrochloric acid, hydrobromic and hydroiodic acids.
- Author:
- Quevauviller, A. et al.
- Year:
- 1 974
- Bibliographic source:
- Annales Pharmaceutiques Françaises, Vol. 32, Iss. 7-8, pp. 421-5
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Evaluation and measurement of burns caused by application of hydrogen bromide (HBr), hydrogen iodide (HI) and hydrogen chloride (HCl) to rat skin.
Test material
- Reference substance name:
- Hydrogen bromide
- EC Number:
- 233-113-0
- EC Name:
- Hydrogen bromide
- Cas Number:
- 10035-10-6
- Molecular formula:
- BrH
- IUPAC Name:
- bromide
- Details on test material:
- Hydrobromic acid
Constituent 1
Test animals
- Species:
- rat
Results and discussion
In vivo
Results
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Reversibility:
- not reversible
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- HBr causes more severe burns to rat skin than HCl or HI.
- Executive summary:
HBr causes more severe burns to rat skin than HCl or HI.
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