Registration Dossier
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EC number: 231-887-4 | CAS number: 7775-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.08 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 17
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Discussion-workers
DNELs for workers[1]
Exposure pattern | Route | Descriptors[2] | DNEL/DMEL (appropriate unit) | Most sensitive endpoint |
Long-term - systemic effects | Oral (mg/kg bw /day) | Not relevant | Not relevant | Not relevant |
Dermal (mg/kg bw /day) | DNEL | 3.08 mg/kg bw/day (215.6 mg/day) | Thyroids follicular hyperactivity | |
Inhalation (mg/m3) | DNEL | 5.0 mg/m3(50 mg/day) | Thyroids follicular hyperactivity |
DNEL-inhalation
DNELacute
A Worker-DNEL-acutefor the inhalatory route has not been derived.
Chapter R8 of the “guidance on information requirements and chemical safety assessment” states “A DNEL for acute toxicity should be derived if an acute toxicity hazard (leading to C&L) has been identified and there is a potential for high peak exposures, for instance when sampling or connecting/disconnecting vessels.This is most relevant for workers exposed to high peak concentrations of volatile and toxic substances”
Sodium chlorate is not classified for acute inhalation toxicity. No effects were observed in an acute inhalation toxicity study.
The vapour pressure is extremely low and thus does not present any potential for inhalation exposure due to volatilization. Furthermore the particle size distribution for sodium chlorate as it is produced shows that 96.35% of the sodium chlorate particles has a diameter >150 µm. Inhalable dust that can reach the upper airways (nose, throat) has a particle diameter < 100 µm and inhalable dust that reaches the lower airways (lungs )has a particle diameter between 5-10 µm.
An acute inhalation study shows no toxicity at the maximizing particle size distribution (1.42 mg/L, MMAD 2.2) or chamber concentration (5.59 mg/L, MMAD 3.0).
Finally high peak exposures do not occur during the manufacturing or use of sodium chlorate.
DNELlongterm
A Worker-DNEL-longtermfor the inhalatory route has been derived. The critical DNEL is 5.0 mg/m3.
DNEL-dermal
DNELacute
A Worker-DNEL-acutefor the dermal route has not been derived.
Chapter R8 of the “guidance on information requirements and chemical safety assessment” states “A DNEL for acute toxicity should be derived if an acute toxicity hazard (leading to C&L) has been identified and there is a potential for high peak exposures, for instance when sampling or connecting/disconnecting vessels.This is most relevant for workers exposed to high peak concentrations of volatile and toxic substances”
Sodium chlorate is not classified for acute dermal toxicity. No effects were observed in an acute dermal toxicity study. Furthermore an in vitro dermal penetration study showed that that the dermal adsorption of sodium chlorate is low, 0.51% and 1.85% of a 5 mg/m2and a 150 µg/m2dose, respectively.
Finallyhigh peak exposures do not occur during the manufacturing or use of sodium chlorate.
DNELlongterm
A Worker-DNEL-longtermfor the dermal route been derived. The critical DNEL is 3.08 mg/kg bw/day.
DNEL-oral
Deriving aDNELfor the oral route is not relevant for workers(R8 p.55).
[1]As the respiration rate is taken into account for the derivation of the DNEL, this table need to be repeated in case different exposure scenarios lead to different respiration rate.
[2]Values inare DNEL/DMEL/ not quantifiable
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.05 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Discussion-general population
DN(M)ELs for general population[1]
Exposure pattern | Route | Descriptors[2] | DNEL/DMEL (appropriate unit) | Most sensitive endpoint |
Long-term - systemic effects | Oral (mg/kg bw /day) | DNEL | 0.05 mg/kg bw/day (3.0 mg/day) | Thyroid follicular cell hypertrophy |
DNELacute
Chapter R8 of the “guidance on information requirements and chemical safety assessment” states “A DNEL for acute toxicity should be derived if an acute toxicity hazard (leading to C&L) has been identified and there is a potential for high peak exposures, for instance when sampling or connecting/disconnecting vessels.This is most relevant for workers exposed to high peak concentrations of volatile and toxic substances”
The substance is not available in consumer available products. However release into the environment is possible. However this will not lead to high peak exposures of the general public. Therefore aDNELacuteis not derived for the general public.
DNELlongterm
Considering the exposure pattern of sodium chlorate consumers are not exposed to sodium chlorate via the use described in section 2. The substance is not available in or released from in consumer availableproducts[a1] . However release into theenvironment is possible[a2] . The major route of environmental exposure of humans to chlorate is through drinking-water (WHO, 2005). Therefore a specific oralDNELlongtermis derived for the general population.
[1]As the respiration rate is taken into account for the derivation of the DNEL, this table need to be repeated in case different exposure scenarios lead to different respiration rate.
[2]Values inare DNEL/DMEL/ not quantifiable
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