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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Study was carried out according to generally valid and internationally accepted testing guidelines and under GLP. Test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
1992
Deviations:
no
Principles of method if other than guideline:
not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspection date : 28/29 November 2002; validity : till 17 July 2004
Type of method:
capillary method
Key result
Melting / freezing pt.:
>= 255 - <= 259.5 °C
Atm. press.:
954 hPa
Remarks on result:
other: standard deviation: ±1°C

The apparatus is designed to determine the melting points of single or mixed solids with recommended maximum melting point of up to 350°C.

It is possible to use the apparatus to determine melting points to a temperature of 450°C although accuracy is impaired. Resolution: 0.1 °C of accuracy, ± 1°C at 350°C.

A heater block is monitored by a type "K" thermocouple linked to an advanced solid state temperature measuring circuit.

Capillary tubes are used. The test item is crunched before use if necessary. Capillary tubes containing the test item are inserted into the heating block.

The rate of heating is 1°C to 2°C per minute until the melting point is observed. The test is performed three times.

The melting point or the melting range of temperatures indicated in this report is the mean of the three assays.

As the difference in temperature between the start and the end of melting is out off the limits of accuracy of the method, a melting range is reported.

Conclusions:
melting point: : 255.0°C - 259.5°C at 954 hPa.
The test item is solid at ambient temperature and pressure.
Executive summary:

The Melting point of test item was determined according to EU method A.1. / OECD 102 guideline (using capillary method) and under GLP as between 255.0 and 259.5°C at 954 hPa

Description of key information

melting point : 255.0–259.5°C at 954 hPa.

The test item is solid at ambient temperature and pressure.

Key value for chemical safety assessment

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study.

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