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Sodium chlorate was not mutagenic in the majority of in vitro studies and in all in vivo systems tested. Sodium chlorate did not induce gene mutations in either bacteria or mammalian cells but the results in E. coli are suggestive of a primary DNA damage with no requirement for metabolic activation. This effect was not confirmed in mammalian HeLa S3 cells in vitro where there was no evidence of unscheduled DNA synthesis. Mechanisms of DNA reparation in bacteria being different from those in mammals, the results observed in mammals are considered more relevant for risk assessment.

In the absence of in vivo genotoxicity in somatic, it was therefore concluded that limited evidence of genotoxicity in vitro in bacteria was not relevant to the in vivo situation.

Therefore, based on both in vitro and in vivo studies, there are sufficient reliable data indicating that sodium chlorate has no genotoxic potential.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on both in vitro and in vivo studies, there are sufficient reliable data indicating that sodium chlorate has no genotoxic potential.