Sodium chlorate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Study was carried out according to generally valid and internationally accepted testing guidelines and under GLP. The substance is considered to be adequately characterised. Therefore full validation applies.

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Version / remarks:

1989

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

Version / remarks:

1992

Deviations:

no

Principles of method if other than guideline:

An estimate of the maximum solubility of the test item in n-octanol was performed by mixing the test item with different amounts of n-octanol for approximately 1 hour at room temperature away from light. After shaking a visual assessment of solubility was made. The solubility in water of the test item was previously determined (7775-09-9, Water solubility, Groult, 2004, RS-28186 PSE).

GLP compliance:

yes

Type of method:

estimation method (solubility ratio)

Remarks:

preliminary test, estimation method

Partition coefficient type:

octanol-water

Type:

log Pow

Partition coefficient:

< -2.9

Temp.:

20 °C

Remarks on result:

other: pH not provided

Type:

Pow

Partition coefficient:

< 0.001

Temp.:

20 °C

Remarks on result:

other: pH not provided

The solutions of the test item in n-octanol were all saturated. The preliminary test indicated that the test item was weakly soluble in n-octanol
(< 1 g/L).   
Estimation based on the individual solubilities of the test item in n-octanol and water:
Pow = Coctanol / Cwater: < (1/717) this is < 0.001and log Pow < -2.9. The HPLC method or shake-flask method were not applicable (log Pow < -2.9) at 20 degrees Celcius.Consequently, the test was considered to be complete. No data on pH and no buffer solution was used. 

Conclusions:

Pow < 0.001 and log Pow < -2.9

Executive summary:

The partition coefficient of test item was determined acccording to OECD guideline 117 / EU method A.8 based on the estimation method (solubility ratio) and under GLP.

Water solubility was determined in section 4.8 as 717 g/L at 20°C and n-octanol solubility was determined as < 1g/L by visual assessment of mixing solutions of test item in n-octanol at different concentrations after shaking for approximately 1 hour at room temperature away from light. Finally, the partition coefficient of the test item was determined as log Pow < -2,9.

This data is considered as a key data.

Description of key information

Pow< 0.001 and

log Pow< -2.9

Weakly soluble in n-octanol

Key value for chemical safety assessment

Log Kow (Log Pow):

-2.9

at the temperature of:

20 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study.