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Additional ecotoxological information

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Administrative data

Endpoint:
additional ecotoxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although not conducted under GLP, nor according to any guideline (and there is none), this is one of the few papers published in this area of increasing interest.

Data source

Reference
Reference Type:
publication
Title:
Quantitative structure-activity relationships for the toxicity to the Tadpole Rana japonica of selected phenols.
Author:
Wang X. et al.
Year:
2000
Bibliographic source:
Bull. Environ. Contam. Toxicol. 64 : 859-865

Materials and methods

Type of study / information:
Memo: The objective is to study the mechanism of acute toxicity of phenols to  frog tadpoles, to investigate interspecies relationship and to further  
develop surrogate organisms for the prediction of acute toxicity of  phenols to tadpoles.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
24 substituted phenol derivatives were provided by the Department of Chemistry at Nanjing University.
They were all of analytical purity and further purification was not necessary.

Results and discussion

Any other information on results incl. tables

For salicylic acid :

log (1/24-hr LC50 on tadpoles) = 2.841 (mol/L)^-1
log BR = 2.488 (mol/L)^-1
log Kow = 2.24
pKa = 2.98

The comparison of the models obtained by regression analysis for tadpoles and for Tetrahymena respectively suggests that
similar mechanisms exist in the two systems. The differences in slopes and intercepts of the log Kow dependent models may
be attributed to the difference in interspecies sensitivity to xenobiotics and to different test media.

The comparison of the toxicity of the phenols in the two test systems showed a good interspecies correlation :
LC50 = 0.95 log BR - 0.15
Hence Tetrahymena pyriformis can serve as a surrogate organism for tadpole toxicity test for polar narcotics and more specific mechanism of toxic action.

Applicant's summary and conclusion