Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comprehensive peer-reviewed safety assessment of MeS providing a detailed review of experimental data on all toxicological endpoints.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
Fragrance material review on methyl salicylate
Author:
Lapczynski A, Jones L, McGinty D et al
Year:
2007
Bibliographic source:
Food Chem Toxicol 45:S428-S452

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Peer-reviewed safety assessment

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
This comprehensive, peer-reviewed, safety assessment of MeS summarises data covering all toxicological endpoints, from both published sources and unpublished reports not otherwise accessible. Data published in this report are considered acceptable for use as supporting information under a number of specific toxicological endpoints.
Executive summary:

This review (Lapczynski et al, 2007) summarises the data on methyl salicylate which is included in the full review of salicylates used as fragrance ingredients by the RIFM Expert Panel.