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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
other: Statistical analysis
Type of information:
other: Statistical evaluation
Adequacy of study:
supporting study
Study period:
not applicable
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Data which do not give sufficient experimental details and which are only listed in this publication. No data on purity.

Data source

Reference
Reference Type:
publication
Title:
Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation.
Author:
Basketter DA, Lea LJ, Cooper K et al
Year:
1999
Bibliographic source:
Food and Chemical Toxicology, 37, 1167-1174

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Statistical analysis of data from LLNA, guinea pig maximisation/Buehler test and human data.
GLP compliance:
not specified
Type of study:
other: Statistical analysis of LLNA and GPMT/BT

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: salicylic acid
no other information

In vivo test system

Test animals

Species:
other: mouse and guinea pig

Study design: in vivo (non-LLNA)

Induction
Vehicle:
no data
Challenge
Vehicle:
no data

Results and discussion

Any other information on results incl. tables

Results for salicylic acid (concentration not stated) :
LLNA : negative (Stimulation Indice < 3)
Guinea pig maximisation test: negative

Human data: negative

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
Classification: not sensitizing