Salicylic acid

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

no data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Single concentration tested. No data on substance purity

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Subacute inhalation toxicity of 109 industrial chemicals

Author:

Gage JC

Year:

1970

Bibliographic source:

Br J Ind Med 27:1-18

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD 412 (Repeat dose study by inhalation, 28-days)

GLP compliance:

no

Test type:

other: Acute toxicity estimated from rpeat dose toxicity study

Test material

Test material information

Constituent 1

Reference substance name:

Methyl salicylate

EC Number:

204-317-7

EC Name:

Methyl salicylate

Cas Number:

119-36-8

Molecular formula:

C8H8O3

IUPAC Name:

Methyl 2-hydroxybenzoate

Test animals

Species:

rat

Strain:

other: Alderley Park

Sex:

female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Duration of exposure:

7 h

Remarks on duration:

7h/day 5d/week 4week

Concentrations:

700 mg/m3

No. of animals per sex per dose:

4

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LCLo

Effect level:

> 700 mg/m³ air (nominal)

Exp. duration:

7 h

Mortality:

None

Any other information on results incl. tables

No toxic signs and no macroscopic or microscopic effects were seen at necropsy following exposure to a saturated atmosphere of methyl salicylate for 7 hours per day, 5 days per week for 4 weeks.

Applicant's summary and conclusion

Interpretation of results:

other: practically non-toxic

Conclusions:

Although this study does not allow any conclusion to be drawn for the possibility of local effects from inhalation of SA dust, it can be predicted that systemic toxicity from SA inhalation would be low.

Executive summary:

4 female Alderley Park rats weighing an average of 200 g were exposed to a dynamic atmosphere (atmosphere continuously generated and passed through the exposure chamber) containing a saturated atmosphere (700 mg/m3) of methyl salicylate for 7 hours per day, 5 days per week for 4 weeks. Food and water were available ad libitum. Animals were weighed each day, and their condition and behaviour were recorded throughout the exposure period. Urine was collected overnight after the last exposure day for biochemical testing. Gross necropsy was conducted as well as microscopic examination of organs. Methyl salicylate at 700 mg/m3 (120 ppm), the maximum achievable atmosphere, did not cause any adverse effects (Gage, 1970). Although this study does not allow any conclusion to be drawn for the possibility of local effects from inhalation of SA dust, it can be predicted that systemic toxicity from SA inhalation would be low.