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Physical & Chemical properties

Partition coefficient

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Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
2.64

Additional information

JUSTIFICATION OF THE WEIGHT OF EVIDENCE APPROACH
The following endpoint study records report fifteen publications, which provide logKow values for salicylic acid with reliability scores of 2, 3 or 4. 

Whatever the method used (shake flask, HPLC, QSAR and titration), the values reported are within the range of -1 to 3.05, leading to the same conclusion (except for the highest one) that the substance has a low potential for bioaccumulation.  

Among these 15 publications, no key study has been selected as none follows the current OECD guidelines nor reports compliance with GLP. Therefore, the weight of evidence approach is applied using studies of reliability scores 2 and 4. One study of reliability 3 has also been integrated into the weight of evidence approach because it used a method sufficiently described and similar to the OECD guideline 117 but under different conditions.

Consequently, this weight of evidence approach uses values in a range from 0.35 to 2.64. The conclusion for this endpoint is that the substance has a low potential for bioaccumulation. The mean value of Log Kow for salicylic acid is around 2.

Table: The LogKow values recorded in this endpoint are listed below. Data in blue are excluded from the weight of evidence approch (invalid value and not assignable method)

P value

Method

ERS ID

2.25 +/- 0.03

HPLC

Part Coeff V2 1984 GARS

2.26

Shake flask-GC

Part Coeff V2 1979FREED

2.21 to 2.26

Shake flask and QSAR

Part Coeff V2 1971LEO

0.35

No data

Part Coeff V2 DOSE

1.47

QSAR

Part Coeff V2 1995MOSC

From 1.13 to 2.64 (see following data)

Part Coeff V2 1989Mackay

 2.26

Shake flask-GC - Sangster 1993

 2.26

Shake flask-GC - Hansch & Anderson 1967 ;

 2.21

Shake Flask - quoted unpublished result Leo et al. 1971

 2.38

Shake flask- AS - Tomida et al. 1978

 2.23 +/-0.03

litterature average - quoted Unger et al. 1978

2.00 +/- 0.01 ; 2.18 +/- 0.01

HPLC - Unger et al. 1978 

2.24 ; 1.97

quoted average and calculated-f constant - Chou & Jurs 1979 

 1.75

Correlated S - Mackay et al. 1980

 2.23

no data - Haky & Young 1984

 2.23

no data - Yalkowski et al. 1983

 2.23

no data - Hansh & Leo 1979 ;;

 2.21

selected best literature value - Garst & wilson 1984 

2.25 +/- 0.03

exp ALPM - Garst & wilson 1984 

1.13, 1.92

correlated HPLC-k' - Haky & Young 1984

2.21

Shake flask at pH 2 - Bundgaard et al. 1986 ; Bundgaard & Nielsen 1988

 2.34

electronic titration - Clarke & Cahoon 1987

 2.24

Shake flask at pH 0.5 - Laznicek et al. 1987

 2.64

CC - Ilchmann et al. 1993 

 2.26

Recommended - Sangster 1993 

2.19 at 37°C

 Shake flask

Part Coeff V3 1985LOFT

2.26

titration method

Part Coeff V3 1986SCHE

2.07

HPLC+phosphatidylcholine coated)

Part Coeff V3 1998HANN-1

3.05

MECC+phosphatidylcholine coated

Part Coeff V3 1998HANN-2

2.13 (37°C)

Part Coeff V3 1979FREES

2.24

Part Coeff V3 2000WANG

-1 at pH6 ; 0.06 à pH 4.6; 1 at pH 3.8; 1.9 at pH 2.8; 2.18 at pH 1.8 and 2.26 at pH 1

Titration method

Part Coeff V3 1977LEPE

2.19

 QSAR

Part Coeff V4 1991JAWO

2.21

Part Coeff V4 1986GHOS