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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
report issued on 16 May 1991
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline-conform study under GLP without deviations
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method
Water solubility:
0.245 mg/L
Temp.:
20 °C
pH:
7 - 8
Details on results:
The solubility of 2-ethylanthraquinone in water at 293 K (20°C) can be calculated as 0.245 mg/L with a coefficient of variation of 11.6 % calculated from 20 determinations.

Solubility of 2-ethylanthraquinone in water using quarts as carrier material and a flow rate of 25 mL/h

Sample number

Time (h)

pH

Concentration (µg/L)

 

 

 

1

2

mean

1

41

7.06

274

276

275

2

48

7.55

269

268

269

3

161

7.53

254

258

256

4

168

7.49

250

256

253

5

185

7.51

275

270

273

The results show that the saturation plateau had been reached. The results are in agreement with the requirements of OECD guideline 105. The results do not differ by more than 30 percent in a random fashion. The mean value of the five mean concentrations is 265 µg/L with a coefficient of variation of 3.8 %.

Solubility of 2-ethylanthraquinone in water using chromosorb as carrier material and a flow rate of 25 mL/h

Sample number

Time (h)

pH

Concentration (µg/L)

 

 

 

1

2

mean

1

114

7.01

254

256

255

2

121

7.34

229

232

231

3

138

7.27

220

222

221

4

142

7.27

238

241

240

5

162

7.36

178

180

179

6

167

7.29

135

120

128

The chromatograms of this test showed many more impurities than the chromatograms of the tests on quartz. These impurities did not influence the determination of 2-ethylanthraquinone. The mean value of the first five concentrations is 225 µg/L with a coefficient of variation of 12.8 %.

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The solubility of the test item in water is 0.245 mg/L at 20°C.
Executive summary:

The water solubility of the test item was assessed according to OECD TG 105 in a valid GLP study.

The tests were performed according to the column elution method with quartz and with chromosorb as carriers. Samples were taken at different timepoints and the test item concentration was determined by HPLC. The solubility of 2-ethylanthraquinone in water at 20°C was calculated from 20 determinations as 0.245 mg/L with a coefficient of variation of 11.6 %.

Description of key information

The solubility of 2-ethylanthraquinone in water is 0.245 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:
0.245 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of 2-ethylanthraquinone was assessed according to OECD TG 105 in a valid GLP study. The test was performed according to the column elution method. The solubility of 2-ethylanthraquinone in water at 20°C was calculated from 20 determinations as 0.245 mg/L with a coefficient of variation of 11.6 %. This value is supported by a QSAR giving a water solubility of 0.4049 mg/L.