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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VII
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 30: 470-476
Reference Type:
study report
Title:
Unnamed
Year:
1961

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A flooding volume of 0.5 ml was instilled directly into the eye of 5 rabbits; eyes were not rinsed. Eye injury was recorded in a 10-grade series
(Grade 1 negligible injury), based upon the degree of corneal injury. See: Carpenter and Smyth, 1946. Chemical Burns of the Rabbit Cornea.
American J. Ophthalmology 29: 1363.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity unknown

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
not reported


ENVIRONMENTAL CONDITIONS
not reported

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
unrinsed
Observation period (in vivo):
18 - 24 h
Number of animals or in vitro replicates:
5

Results and discussion

In vivo

Results
Irritation parameter:
other: irritation
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
> 0
Remarks on result:
other: Propyl acetate was designated Grade 2 on a scale of 10 (slight irritation). These results indicate that n-propyl acetate causes minimal corneal injury.

Any other information on results incl. tables

The corneal injury in rabbits was reported in Smyth et al. 1969 as grade 2 (0.5 ml undiluted gives injury of over 1.0 up to 5.0 points). OECD SIDS reported that "instillation of an excess amount of undiluted propyl acetate into the rabbit eye produced some diffuse corneal injury, which healed quickly. Propyl acetate was designated Grade 2 on a scale of 10 (slight irritation). These results indicate that n-propyl acetate causes minimal corneal injury."

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Remarks:
Migrated information