Registration Dossier
Registration Dossier
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EC number: 203-686-1 | CAS number: 109-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Neurotoxicity
Administrative data
Description of key information
Propyl acetate
Rat, inhalation, motoneuronal EC37: ca. 27.5 mg/L (Frantik et al. 1994)
Mouse, inhalation, motoneuronal EC30: ca. 26 mg/L (Frantik et al. 1994)
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Propyl acetate
Groups of 4 male albino SPF-Wistar rats or 4 female H strain mice were exposed individually for 4 hours to a range of propyl acetate concentrations (analytically determined; Frantik et al. 1994). Measurement of any potential neurotoxic effect started within one minute after removal from exposure. A short electrical impulse (0.2 sec, 50 Hz, 180 V) was applied through ear electrodes. The duration of tonic extension of the hindlimbs in exposed and control rats was measured. All animals were given three control tests at weekly intervals prior to the first exposure. The concentration which resulted in a 37% (EC37) decrease in rat hindlimb extension during electrically-induced seizure events was 6600 ppm (+/- 1200 ppm) or 27.522 mg/L (+/- 5.004 mg/L), while the concentration which resulted in a 30% (EC30) decrease in mouse hindlimb extension during electrically-induced seizure events was 6200 ppm (+/- 830 ppm) or 25.854 mg/L (+/- 3.461 mg/L)
Justification for classification or non-classification
Taken together all available data for propyl acetate, there were no irreversible subchronic neurotoxic effects in doses without systemic toxicity. Therefore no classification is required.
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