Registration Dossier
Registration Dossier
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EC number: 203-686-1 | CAS number: 109-60-4
Neurotoxicity
Administrative data
Description of key information
Propyl acetate
Rat, inhalation, motoneuronal EC37: ca. 27.5 mg/L (Frantik et al. 1994)
Mouse, inhalation, motoneuronal EC30: ca. 26 mg/L (Frantik et al. 1994)
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Propyl acetate
Groups of 4 male albino SPF-Wistar rats or 4 female H strain mice were exposed individually for 4 hours to a range of propyl acetate concentrations (analytically determined; Frantik et al. 1994). Measurement of any potential neurotoxic effect started within one minute after removal from exposure. A short electrical impulse (0.2 sec, 50 Hz, 180 V) was applied through ear electrodes. The duration of tonic extension of the hindlimbs in exposed and control rats was measured. All animals were given three control tests at weekly intervals prior to the first exposure. The concentration which resulted in a 37% (EC37) decrease in rat hindlimb extension during electrically-induced seizure events was 6600 ppm (+/- 1200 ppm) or 27.522 mg/L (+/- 5.004 mg/L), while the concentration which resulted in a 30% (EC30) decrease in mouse hindlimb extension during electrically-induced seizure events was 6200 ppm (+/- 830 ppm) or 25.854 mg/L (+/- 3.461 mg/L)
Justification for classification or non-classification
Taken together all available data for propyl acetate, there were no irreversible subchronic neurotoxic effects in doses without systemic toxicity. Therefore no classification is required.
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