Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficent for assessment

Data source

Reference
Reference Type:
publication
Title:
Zur Toxikologie der Loesungsmittel. (Several Ester, Aceton, Methylalkohol.)
Author:
Flury F, Wirth W
Year:
1933
Bibliographic source:
Archiv f. Gewerbepath. u. Gewerbehyg. 5, 1-90, 1933

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
other: serval endpoints addressed
Principles of method if other than guideline:
Short term inhalation study with volunteers (5 min, 4 subjects).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
other: volunteers, unspecified
Subjects:
2-4
Ethical approval:
not specified
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
measured

Results and discussion

Any other information on results incl. tables

After exposure to a concentration of 1000 mg/m3 (236 ml/m3), very slight irritation effects in eyes, nose and pharynx were observed.

After exposure to 15000 mg/m 3 (3500 ml/m3) slight irritation effects in eyes, nose, pharynx and upper respiratory tract were observed.

Additionally, cold feeling, dryness in the pharynx and upper respiratory tract and slight discharge was observed only in the high dose.

Applicant's summary and conclusion