Registration Dossier
Registration Dossier
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EC number: 204-853-1 | CAS number: 127-63-9
Endpoint summary
Administrative data
Description of key information
Additional information
The hydrolysis study of Diphenyl sulphone was conducted according to the standard OECD guideline 111. The preliminary test for hydrolysis of Diphenyl sulphone was conducted at 50 ± 0.5°C in the dark at pH 4, 7 and 9 buffer solutions for a period of 5 days. Based on the preliminary test data generated in this study, Diphenyl sulphone was found hydrolytically stable, with less than 10% degradation at each pH, which would indicate a DT50 of >1 year at 25°C. So according to the instructions of the test guideline, an additional test was not conducted. The biodegradation of DPS in water was determined in a 28day-ready-biodegradability test with carbon dioxide evolution (OECD 301 B). The substance was biodegraded for 0-5%, hence the substance is not ready biodegradable under the standard test conditions. The biodegradation of DPS was also determined in a standard simulation test in natural water (OECD 309) with [14C]-Diphenyl Sulphone. The degradation rate and degradation products were measured. Two different concentrations (10 μg/L and 95 μg/L) were applied. The mineralisation rate was negligible. The DT50 values for [14C]-Diphenyl Sulphone were determined to be 800 days (10 μg/L) and 1210 days (95 μg/L) in the water phases. Therefore, [14C]-Diphenyl Sulphone is very persistent. Only very low amounts were trapped as [14C]-CO2. (0.1% for 10µg/L, <LOQ for 95 µg/L).No degradation product were measured.
According to the standard information requirements in Annex IX point 9.3.2 column 2, a bioaccumulation study does not need to be conducted if the substance has a low potential for bioaccumulation i.e. if the log Pow <3. The log Pow of diphenyl sulphone is 2.60. The bioaccumulation potential of diphenyl sulphone is low and a bioaccumulation study does not has to be conducted.
According to the standard information requirements in Annex VIII point 9.3.1 column 2, an adsorption/desorption study can be waived if the substance has a low potential for bioaccumulation i.e. if the log Kow <3. The log Kow of diphenylsulfone is 2.60. The bioaccumulation potential of diphenyl sulphone is low and an adsorption/desorption study does not have to be conducted.
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