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EC number: 204-853-1 | CAS number: 127-63-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Diphenyl sulphone
- EC Number:
- 204-853-1
- EC Name:
- Diphenyl sulphone
- Cas Number:
- 127-63-9
- Molecular formula:
- C12H10O2S
- IUPAC Name:
- (benzenesulfonyl)benzene
- Details on test material:
- - Name of test material (as cited in study report): DIPHENYLSULFON
- Substance type: organic
- Physical state: solid, white crystalline
- Analytical purity: > 99%
- Purity test date: 22/09/2001
- Lot/batch No.: 2111 SA
- Expiration date of the lot/batch: 22/09/2002
- Stability under test conditions: not indicated
- Storage condition of test material: room temperature in the dark
- Other:
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, Margate, Kent, UK
- Age at study initiation: eight weeks of age
- Weight at study initiation: 179 to 272 g
- Fasting period before study: an overnight fast immediately before dosing and for approximately three to four hours after dosing
- Housing: they were housed in groups of three by sex in solid-floor polypropylene cages furnished with woodflakes.
- Diet (e.g. ad libitum): free access to food, certified rat and mouse diet (code 5LF2) supplied by PMI Nutrition International, Nottingham, UK) was allowed throughout the study. The diet, drinking water and bedding were routinely analysed and were considered not to contain any contaminants that would be reasonably be expected to affect the purpose or integrity of the study.
- Water (e.g. ad libitum): ad libitum
- Acclimation period: an acclimatisation period of at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25°c
- Humidity (%): 30 - 70%
- Air changes (per hr): 15
- Photoperiod: 12 hrs dark / 12 hrs light, controlled by a time switch
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 - 20 mg/ml
- Amount of vehicle (if gavage): /
- Justification for choice of vehicle:/
- Lot/batch no. (if required): /
- Purity: /
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/ml
DOSAGE PREPARATION (if unusual):as a suspension
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: based on the results from this dose level further groups of fasted animals were treated at a dose level of 200 mg/kg bodyweight. - Doses:
- 200 - 2000 mg/kg
- No. of animals per sex per dose:
- 3 females: 2000 mg/kg
3 males and 3 females: 2000 mg/kg - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: the animals were observed for deaths or overt signs of toxicity 1/2, 1, 2 and 4 hours after dosing and subsequently once daily for up to 14 days.
- Frequency of observations and weighing: individual bodyweights were recorded prior to dosing and 7 and 14 days after treatment or at death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, mortality data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 300 - 500 mg/kg bw
- Mortality:
- All animals treated at a dose level of 2000 mg/kg were killed in extremis one day after dosing.
No deaths were noted at a dose level of 200 mg/kg. - Clinical signs:
- other: Signs of systemic toxicity noted in animals treated at a dose level of 2000 mg/kg were ataxia, hunched posture, lethargy, ptosis, decreased respiratory rate, laboured and gasping respiration, loss of righting reflex, exophthalmos, hypothermia and dehydrat
- Gross pathology:
- Abnormalities noted at necropsy of animals that were killed in extremis during the study were abnormally red lungs, patchy pallor of the liver, pale kidneys and haemorrhagic small intestine.
no abnormallities were noted at necropsy of animals that were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of the test material in the Sprague-Dawley CD (Crl: CD® (SD) IGS BR) strain rat was estimated to be in the range of 300 - 500 mg/kg bodyweight.
The test material was classified as HARMFUL and the symbol 'Xn' and risk phrase R 22 'HARMFUL IF SWALLOWED' are required according the EU labelling reulations Commision directive 93/21/EEC
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