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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2020
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
ISO 13320:2009
Deviations:
no
Principles of method if other than guideline:
As a pre-treatment on the Particle size analysis with laser diffraction ,the test sample was first sieved through a 500 µm sieve (DIN 4188)
GLP compliance:
yes
Type of method:
Laser scattering/diffraction
Mass median aerodynamic diameter:
326 µm
Geometric standard deviation:
2.318
Key result
Percentile:
D10
Mean:
95.8 µm
St. dev.:
3.66
Remarks on result:
other: result obtained after sieving with a 500 µm sieve
Key result
Percentile:
D50
Mean:
393 µm
St. dev.:
4.66
Remarks on result:
other: result obtained after sieving with 500 µm sieve
Key result
Percentile:
D90
Mean:
743 µm
Remarks on result:
other: result obtained after sieving with a 500 µm sieve

   Run 1  Run 2 Run 3  Run 4   Run 5 Mean  STDVP  %STDVP 
 Volume weighted mean 418  415  405   408 438  417  13   3.12
 Mode 452  454  453  450 447  451 2.54  0.564
 d 10  97.4 95.2  90.0  96.3  99.9  95.8  3.66  3.82 
 d 50 396   393 384  390  398  393  4.66  1.19 
 d 90 745  744  727  726  775  743   19.8 2.66 
 GSD 2.314  2.323  2.338  2.283  2.330  2.318  0.021  0.916 
 MMAD  326              
Conclusions:
The majority (82.6 %) of the particles were foud to be in the size of >500 µm.
The particle size distribution of the paticles < than 500 µm has a median particle size of d 50= 393 µm which was determined by laser diffraction
Executive summary:

The majority (82.6 %) of the test item particles were foud to be in the size of >500 µm.

The particle size distribution of the test item sample fraction after sieving with a 500 µm sieve was determined by means of Laser Diffraction Analysis using the medium volume (wet) module (MVM).

The d50 of the test item sample fraction after sieving with a 500 µm sieve was determined to be 393 µm, the d10 was 95.8 µm and the d90 was 743 µm. The MMAD of the test item sample fraction after sieving with a 500 µm sieve, for the relative density and the mean d50, was calculated to be 326 µm.

Description of key information

A Particle Size Analysis  is executed  by Charles River on diphenyl sulphone. This study is according to method  ISO 13320:2009 Particle Size –Laser Diffraction  Methods. 2009. In preparation to this Particle Size-laser diffraction method the  test item was sieved with a 500 µm sieve.

The majority (82.6 %) of the test item particles were foud to be in the size of >500 µm.

The particle size distribution of the test item sample fraction after sieving with a 500 µm sieve was determined by means of Laser Diffraction Analysis using the medium volume (wet) module (MVM).

The d50 of the test item sample fraction after sieving with a 500 µm sieve was determined to be 393 µm, the d10 was 95.8 µm and the d90 was 743 µm. The MMAD of the test item sample fraction after sieving with a 500 µm sieve, for the relative density and the mean d50, was calculated to be 326 µm.

Additional information