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Description of key information

inhalation is the relevant rout of exposure for this volatile substance. There were no signs of toxicity in rats exposed to 4.5 mg/m³ (1 ppm = NOAEC)

Key value for chemical safety assessment

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEC
4.5 mg/m³
Study duration:
subacute
Species:
rat

Additional information

In a screening study with 109 chemicals, male and female (4/sex/dose) rats of an in-house strain (Alderley Park, UK) were exposed to 4.5, 22.6 or 90.2 mg/m³ EtCF (1, 5, or 20 ppm nominal)for 6 h/day, 5 d/wk for up to 4 weeks (20 exposures at first two doses, 10 exposures at highest dose). The study was equivalent to an OECD TG 412 study although there are some restrictions concerning documentation and testing protocol (Gage, 1970). There were no signs of toxicity in rats exposed to 4.5 mg/m³ (1 ppm = NOAEC). Rats exposed to 22.6 mg/m³ had reduced weight gains but normal appearing organs at necropsy. Rats exposed to 20 ppm exhibited nasal irritation, difficulty with respiration, poor condition, and weight loss. Autopsies of these animals revealed distension and haemorrhage of the lungs.


Repeated dose toxicity: inhalation - systemic effects (target organ) respiratory: nose

Justification for classification or non-classification

No classification concerning repeated dose toxicity is warranted as classification criteria accordin to EU Regulation 67/548 and EU Regulation 1272/2008 are not met.