Registration Dossier
Registration Dossier
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EC number: 208-778-5 | CAS number: 541-41-3
Endpoint summary
Administrative data
Description of key information
inhalation is the relevant rout of exposure for this volatile substance. There were no signs of toxicity in rats exposed to 4.5 mg/m³ (1 ppm = NOAEC)
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 4.5 mg/m³
- Study duration:
- subacute
- Species:
- rat
Additional information
In a screening study with 109 chemicals, male and female (4/sex/dose) rats of an in-house strain (Alderley Park, UK) were exposed to 4.5, 22.6 or 90.2 mg/m³ EtCF (1, 5, or 20 ppm nominal)for 6 h/day, 5 d/wk for up to 4 weeks (20 exposures at first two doses, 10 exposures at highest dose). The study was equivalent to an OECD TG 412 study although there are some restrictions concerning documentation and testing protocol (Gage, 1970). There were no signs of toxicity in rats exposed to 4.5 mg/m³ (1 ppm = NOAEC). Rats exposed to 22.6 mg/m³ had reduced weight gains but normal appearing organs at necropsy. Rats exposed to 20 ppm exhibited nasal irritation, difficulty with respiration, poor condition, and weight loss. Autopsies of these animals revealed distension and haemorrhage of the lungs.
Repeated dose toxicity: inhalation - systemic effects (target organ) respiratory: nose
Justification for classification or non-classification
No classification concerning repeated dose toxicity is warranted as classification criteria accordin to EU Regulation 67/548 and EU Regulation 1272/2008 are not met.
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